Cancer Screening Panel Tests (Female): Introduction, Related assays, and Keynotes

Cancer Screening Panel Tests-Female

Cancer screening panel tests are a group of medical tests that are designed to detect different types of cancer in the body. These tests can be used to screen for cancer in individuals who do not have any symptoms or to monitor individuals who have been diagnosed with cancer and are undergoing treatment.

Some of the common cancer screening panel tests include:

  1. Pap smear: A Pap smear is a test used to screen for cervical cancer in women. During the test, a sample of cells is collected from the cervix and examined under a microscope for abnormal cells.
  2. Mammography: A mammogram is an X-ray of the breast tissue that is used to detect breast cancer in women.
  3. Colonoscopy: A colonoscopy is a test used to screen for colon cancer. During the test, a flexible tube with a camera on the end is inserted into the rectum to examine the inside of the colon.
  4. Lung cancer screening: Low-dose CT scans are used to screen for lung cancer in individuals who are at high risk of developing the disease, such as heavy smokers.

It’s important to note that not all cancers can be detected through screening tests, and some screening tests may have limitations, such as a high false-positive rate or the need for further testing to confirm a diagnosis. It’s also important to discuss the benefits and limitations of screening tests with a healthcare provider to determine the best course of action for an individual’s specific situation.

Package Contents for Cancer Screening Panel Tests

Cancer Screening Panel tests (Female) include:

  • CBC-
  • ESR-
  • CA 125-
  • CA 15.3-
  • CEA-
  • AFP-
  • Beta HCG-

Note: Prostate-specific antigen (PSA) test: The PSA test is a blood test that is used to screen for prostate cancer in men. It measures the level of PSA in the blood, which can be elevated in men with prostate cancer.

CBC

A complete blood cell count (CBC) is a common blood test that measures different components of blood, including red blood cells, white blood cells, and platelets. The results of a CBC can provide important information about a person’s overall health and help diagnose a variety of medical conditions.

Red blood cells are responsible for carrying oxygen throughout the body, and their count, size, and shape can provide information about a person’s risk of anemia or other blood disorders. White blood cells are part of the body’s immune system and help fight infections, so their count and type can indicate the presence of an infection or inflammation. Platelets play a crucial role in blood clotting, and their count can indicate the risk of bleeding disorders.

A CBC typically includes measurements of the following components:

  • Red blood cell count (RBC)
  • Hemoglobin (Hb)
  • Hematocrit (Hct)
  • Mean corpuscular volume (MCV)
  • Mean corpuscular hemoglobin (MCH)
  • Mean corpuscular hemoglobin concentration (MCHC)
  • Red cell distribution width (RDW)
  • White blood cell count (WBC)
  • Platelet count

The CBC is a simple and common test that is typically ordered as part of a routine physical examination or to diagnose or monitor a wide range of medical conditions. It is performed by taking a small sample of blood from a vein in the arm and analyzing it in a laboratory. The results are usually available within a few hours to a few days, depending on the laboratory.

ESR

The erythrocyte sedimentation rate (ESR) test, also known as the sedimentation rate (sed rate) test, is a blood test that measures how quickly red blood cells settle to the bottom of a tube of blood. This test is often used to help diagnose or monitor inflammatory conditions, such as rheumatoid arthritis, lupus, or infections.

During the ESR test, a small amount of blood is drawn from a vein in the arm and placed into a tall, thin tube. The tube is then left undisturbed for one hour, allowing the red blood cells to settle to the bottom. The ESR is determined by measuring the distance between the top of the clear liquid (plasma) and the top of the settled red blood cells.

If there is inflammation in the body, certain proteins, such as fibrinogen and immunoglobulins, can cause the red blood cells to stick together and settle faster than usual, resulting in a higher ESR. The ESR test is not specific to any particular disease, but it can indicate the presence of inflammation in the body, which can be caused by a variety of conditions.

It is important to note that a high ESR does not necessarily mean that a person has a specific disease or condition, and further testing may be required to determine the cause of the inflammation. Additionally, other factors, such as age, gender, and medications, can also affect the ESR results.

Overall, the ESR test is a simple and useful tool for detecting inflammation in the body, but it should be interpreted in conjunction with other clinical and laboratory findings to determine the underlying cause of the inflammation.

CA125

The CA 125 test is a blood test that measures the level of CA 125 in the blood. CA 125 is a protein that is produced by cells in the body, and elevated levels of this protein can indicate certain medical conditions, particularly ovarian cancer.

The CA 125 test is often used as a tumor marker for ovarian cancer, but it is not specific to this type of cancer, and elevated levels can also be seen in other conditions, such as endometriosis, uterine fibroids, and even during menstruation.

It is important to note that the CA 125 test is not a screening test for ovarian cancer, and should not be used alone to diagnose or rule out the disease. Other diagnostic tests, such as imaging studies, may be necessary to confirm or rule out the presence of cancer.

If you are concerned about ovarian cancer or other medical conditions, it is best to talk to your healthcare provider who can help you determine the appropriate diagnostic tests and treatment options.

CA 15-3

The CA 15-3 test is a blood test that measures the level of a protein called cancer antigen 15-3 (CA 15-3) in the blood. CA 15-3 is a tumor marker that is often used in the diagnosis and monitoring of breast cancer.

CA 15-3 is produced by certain types of cancer cells, including breast cancer cells, and can be found in higher levels in the blood of some people with breast cancer. However, not all people with breast cancer will have elevated CA 15-3 levels, and some people without breast cancer may have elevated levels of CA 15-3 for other reasons.

The CA 15-3 test is not a definitive diagnostic test for breast cancer, and it is not recommended as a screening test for breast cancer in people without symptoms or a high risk of the disease. Instead, it is primarily used to monitor the response to treatment in people with known breast cancer, and to detect the recurrence of breast cancer in people who have previously been treated for the disease.

If you are concerned about breast cancer or have been diagnosed with breast cancer, it is important to talk to your doctor about the most appropriate tests and monitoring strategies for your individual situation.

CEA Test

CEA stands for carcinoembryonic antigen, and this test is a blood test that measures the level of CEA in the blood. It is a protein that is produced by some types of cancer cells, including colorectal, lung, pancreatic, and breast cancer cells.

The CEA test is not a definitive diagnostic test for cancer, and elevated levels of CEA in the blood can be caused by other non-cancerous conditions such as smoking, infections, and inflammatory bowel disease. Therefore, the CEA test is not used as a screening test for cancer in people without symptoms or a high risk of the disease.

The CEA test is primarily used to monitor the response to treatment in people with known cancer and to detect the recurrence of cancer in people who have previously been treated for the disease. In people with colorectal cancer, the CEA test may be used to monitor the effectiveness of surgery and chemotherapy, and to detect any recurrence of the disease.

It is important to note that a normal CEA level does not necessarily mean that cancer is not present, as not all types of cancer produce CEA, and some people with cancer may have normal CEA levels. Therefore, the CEA test is typically used in combination with other diagnostic tests and imaging studies to diagnose and monitor cancer.

If you are concerned about cancer or have been diagnosed with cancer, it is important to talk to your doctor about the most appropriate tests and monitoring strategies for your individual situation.

AFP Test

The AFP test is a blood test that measures the level of alpha-fetoprotein (AFP) in the blood. AFP is a protein that is produced by the developing fetus during pregnancy, but its production normally decreases after birth. In adults, elevated levels of AFP in the blood may be a sign of certain types of cancer, including liver cancer, testicular cancer, and ovarian cancer.

The AFP test is not a definitive diagnostic test for cancer, and elevated levels of AFP in the blood can also be caused by other non-cancerous conditions, such as cirrhosis of the liver, hepatitis, and pregnancy. Therefore, the AFP test is not used as a screening test for cancer in people without symptoms or a high risk of the disease.

The AFP test is primarily used to monitor the response to treatment in people with known cancer and to detect the recurrence of cancer in people who have previously been treated for the disease. In people with liver cancer, the AFP test may be used to monitor the effectiveness of treatment and to detect any recurrence of the disease.

It is important to note that a normal AFP level does not necessarily mean that cancer is not present, as not all types of cancer produce AFP, and some people with cancer may have normal AFP levels. Therefore, the AFP test is typically used in combination with other diagnostic tests and imaging studies to diagnose and monitor cancer.

If you are concerned about cancer or have been diagnosed with cancer, it is important to talk to your doctor about the most appropriate tests and monitoring strategies for your individual situation.

Beta HCG

Beta HCG stands for Beta Human Chorionic Gonadotropin. It is a hormone produced during pregnancy, specifically by the placenta after a fertilized egg has implanted in the uterus. Beta HCG can be detected in the blood or urine and is commonly used in pregnancy tests.

Beta HCG levels rise rapidly in the first few weeks of pregnancy, doubling every two to three days, and then start to level off around 10-12 weeks of pregnancy. Abnormal levels of beta HCG can indicate a problem with the pregnancy, such as a possible miscarriage or ectopic pregnancy.

In addition to its use in pregnancy testing, beta HCG levels can also be used to diagnose and monitor certain types of cancer, such as testicular cancer, ovarian cancer, and trophoblastic disease.

Further Readings

  1. Clinical Hematology Atlas-Jacqueline H. Carr, Bernadette F. Rodak
  2. Diagnostic Hematology-Bernadette F. Rodak
  3. Hematology: Clinical Principles and Applications-Bernadette F. Rodak, George A. Fritsma, Kathryn Doig
  4. Clinical Hematology-Neal S. Young, Stanton L. Gerson, Katherine A. High
  5. Bethesda Handbook of Clinical Hematology-Griffin P. Rodgers, Neal S. Young
  6. Wintrobe’s Atlas of Clinical Hematology-Babette Weksler
  7. Atlas of Bone Marrow Pathology-Tracy I. George, Daniel A. Arber
  8. Atlas of Peripheral Blood: The Primary Diagnostic Tool-Irma Pereira, Tracy I. George, Daniel A. Arber
  9. Hematopathology-Elaine Sarkin Jaffe, Daniel A. Arber, Elias MD Campo, Leticia Quintanilla-Martinez, Nancy Lee L. Harris
  10. Abeloff’s Clinical Oncology, 6th Edition-John E. Niederhuber & James O. Armitage & James H Doroshow & Michael B. Kastan & Joel E. Tepper
  11. Clinical Immuno-Oncology, 1st Edition-John E. Niederhuber
  12. Breast Cancer, 1st Edition-James L. Weese
  13. Advances in Oncology, 2021, 1st Edition-Leonidas C. Platanias

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