Histoplasma-Antibody Testing: Introduction, Principle, Clinical Significance, and Keynotes

Introduction Histoplasma capsulatum is a dimorphic fungus responsible for histoplasmosis, a systemic mycosis prevalent in endemic regions such as the Ohio and Mississippi River valleys, parts of Latin America, Africa, and Asia. Rapid and reliable diagnosis is crucial since clinical features may mimic tuberculosis, malignancy, …

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COVID-19 Antigen Test- Introduction, Principle, Test Requirements, Procedure, Result Interpretation, Clinical Significance and Disadvantage

COVID-19 Antigen Test-Positive

Introduction of COVID-19 Antigen Test SARS-CoV-2 antigen test for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is used as a screening test on asymptomatic persons to detect or exclude Coronavirus Disease 2019 (COVID-19) or to determine whether a person who previously was diagnosed with COVID-19 …

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Candida-Antibody Testing-Introduction, Principle, Purpose, Types of antibody tests, Limitation, and More

Candida albicans growth on Biphasic medium (BHI agar and broth)-right (turbid)- No growth on left (clear)

Introduction Candida antibody testing measures immunoglobulins (IgG, IgA, and IgM) antibodies in the blood to help detect current or past Candida infections. These antibodies are produced in response to the presence of Candida in the body, assisting the immune system in fighting off the fungus. Principle Purpose …

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Cryptococcal Antigen (CrAg) Testing-Introduction, Principle, Sample used, Detection Methods, Clinical Significance, Limitations, and Keynotes

Cryptococcal Antigen (CrAg) Testing-Introduction, Principle, Sample used, Detection Methods, Clinical Significance, Limitations, and Keynotes

Introduction of Cryptococcal Antigen (CrAg) Testing  Cryptococcal antigen (CrAg) testing detects the presence of antigens produced by the Cryptococcus fungus in body fluids, aiding in the diagnosis of cryptococcosis, particularly meningitis. This test helps identify infection early, even before visible symptoms appear, and is crucial for timely …

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Coccidioides-Antigen Testing: Introduction, Purpose, How it works, When it’s used, Types of antigen tests, Limitation, and More

Introduction Coccidioides antigen testing, used to diagnose coccidioidomycosis (also known as valley fever),  detects the presence of fungal antigens in bodily fluids like urine, serum, or cerebrospinal fluid. This aids in faster and more accurate diagnosis, especially in immunocompromised individuals or those with severe disease.  …

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Influenza A and Influenza B Rapid Test: Introduction, Principle, Procedure, Result-Interpretation, Clinical Significance and Keynotes

Influenza A and Influenza B Rapid Test-Negative

Introduction This test rapidly detects influenza A and B antigens. It employs a chromatographic assay format. Moreover, it is simple to perform. Principle The test uses immunochromatography. It employs specific antibodies to bind viral antigens. Furthermore, it uses color changes for detection. Thus, it yields …

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Paracoccidioides-Antibody Testing: Introduction, Principle, Clinical Significance, and Keynotes

Paracoccidioides-Antibody Testing- Introduction, Principle, Clinical Significance, and Keynotes

Introduction Paracoccidioides antibody testing detects antibodies against the Paracoccidioides species. It plays a vital role in diagnosing paracoccidioidomycosis (PCM). Additionally, clinicians use this test to confirm suspected cases. Moreover, the assay identifies immune responses in patient serum. Furthermore, laboratories perform standardized serological tests such as …

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Complement Fixation Test-Introduction, Principle, Testing Procedure, Result -Interpretation, and Keynotes

Complement Fixation Test (CFT) Result -Interpretation

Introduction Complement Fixation Test is a classical assay that detects specific antibodies in patient serum samples. The test employs complement proteins to reveal immune reactions between antigens and antibodies with accuracy. Moreover, the assay fixes complement when antigen-antibody complexes form quickly during incubation under controlled …

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