Histoplasma-Antigen Testing Introduction, Principle, Clinical Significance, and Keynotes
Table of Contents
Histoplasma capsulatum is a dimorphic fungus responsible for histoplasmosis, an endemic mycosis prevalent in parts of North and Central America, Africa, and Asia. In immunocompromised patients, especially those with HIV/AIDS, cancer, or organ transplants, histoplasmosis can be severe and disseminated. Histoplasma antigen testing provides a rapid, sensitive, non-culture method to detect fungal antigens in body fluids, helping overcome the limitations of slow, low-yield culture-based diagnosis.
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