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Vibrio cholerae: Introduction, Identification Features, Keynotes, and Vibrio Footages

Introduction

The genus, Vibrio is a member of the family, Vibrionaceae and the most common human pathogens are Vibrio cholerae, V. parahaemolyticus, and V. vulnificus. Vibrio cholerae is a species of Gram-negative, motile, non-sporing, and non-capsulated, facultative anaerobe and comma-shaped bacterium. It is a ubiquitous and abundant aquatic environment. Some strains of V. cholerae are pathogenic to humans and cause the deadly disease cholera, which can be occurred from the consumption of undercooked or raw marine life species. It was first described by Félix-Archimède Pouchet in 1849 and he thought it was some kind of protozoa but later confirmed by Filippo Pacini correctly identified it as a bacterium.

The causative agent of cholera was confirmed by Robert Koch in 1884 whereas Sambhu Nath De isolated the cholera toxin. He demonstrated the toxin as the cause of cholera in 1959. Two serogroups called O1 and O139 are responsible for cholera outbreaks. Diarrhea and vomiting are two clinical features of cholera patients within several hours to 2–3 days of ingestion. Oral rehydration solution (ORS) and antibiotics (fluoroquinolones and tetracyclines) are the common treatment procedure.

Fig. 1. Rice water stool in a container, 2. Prepared hanging drop ready for observation,3. V. cholerae dipstick test positive, 4 V. cholerae growth on TCBS agar, 5. Biochemical reaction of V. cholerae in TSI, SIM, and Citrate agar, 6. String test positive and 7. V. cholerae serotyping

Biochemical Tests of Vibrio cholerae

Basic FeaturesProperties
1. Gram StainingGram-Negative Rods (GNRs)
2. SporeNon-Sporing
3. CapsuleNegative
4. MotilityPositive
5. PigmentNegative
6. String TestPositive
7. Catalase testPositive
8. Oxidase testPositive
9. Nitrate reduction testPositive
10. MR (Methyl Red) testNegative
11. VP (Voges- Proskauer) assayVariable
12. OF (Oxidative-Fermentative) testoxidative/obligate aerobes
13. GasNegative
14. H2S productionNegative
15. Indole formationPositive
16. Urease/ urea hydrolysis testNegative
17. Citrate/ citrate utilizationVariable
18. DNase testNegative
19. Glucose fermentationPositive
20. Maltose fermentationPositive
21. Lactose fermentationVariable
22. Sucrose fermentationPositive
23. Xylose fermentationNegative
24. Mannitol fermentationPositive
25. Acetate UtilizationPositive
26. ONPG (β-galactosidase)Positive
27. Phenylalanine Deaminase (PDA)/PPA TestNegative
28. Lipase testPositive
29. Esculin Hydrolysis testNegative
30. Lysine Decarboxylase TestPositive
31. Ornithine Decarboxylase TestPositive
32. Arginine Dihydrolase TestNegative
Table: Properties of Vibrio cholerae

Keynotes on Vibrio

  • Vibrio species are responsible for the majority of human diseases attributed to the natural microbiota of aquatic environments and seafood; the most common pathogenic species are V. cholerae, V. parahaemolyticus, V. vulnificus and V. alginolyticus.
  • Vibrio cholerae has two circular DNA and one of them produces the cholera toxin (CT), a protein that causes profuse, watery diarrhea and it is also called rice-water stool.

Vibrio Footages

Rice water stool of a cholera patient

Fig. Rice water stool of a cholera patient

Prepared hanging drop for Darting motility

Fig. Prepared hanging drop for Darting motility

Hanging drop positive for Darting motility of Vibrio cholerae

Fig. Hanging drop positive for Darting motility of V. cholerae at a magnification of 400X

Cholera Dipstick Test Positive

Fig. Cholera Dipstick Test Positive

Cholera Dipstick Test Negative

Fig. Cholera Dipstick Test Negative

Vibrio cholerae growth on TCBS agar of watery diarrhoea culture

Fig. V. cholerae growth on TCBS agar of watery diarrhea culture

Pure well isolated Vibrio cholerae yellow colony on TCBS agar

Fig. Pure well isolated V. cholerae yellow colony on TCBS agar

Gram-negative curved bacillus or comma-shaped Vibrio cholerae in Gram staining of culture

Fig. Gram-negative curved bacillus or comma-shaped V. cholerae in Gram staining of culture at a magnification of 2000X

Vibrio cholerae Biochemical Reactions in TSI, SIM, Citrate and Urea agar

Fig. V. cholerae Biochemical Reactions in TSI, SIM, Citrate, and Urea agar

Oxidation-fermentation (OF) test and Decaboxylase test of Vibrio cholerae

Fig. Oxidation-fermentation (OF) test and Decarboxylase test of V. cholerae

Vibrio cholerae Antisera for O139 (Bengal), serovar Inaba and serovar Odawa

Fig. V. cholerae Antisera for O139 (Bengal), serovar Inaba and serovar Odawa

Vibrio cholerae serotyping for O139 (Bengal)

Fig. V. cholerae serotyping for O139 (Bengal)

String Test Positive Vibrio cholerae

Fig. String Test Positive V. cholerae

Vibrio cholerae colony morphology on nutrient agar

Fig. V. cholerae colony morphology on nutrient agar

Vibrio cholerae colony morphology on 5% sheep blood agar

Fig. V. cholerae colony morphology on 5% sheep blood agar

Vibrio cholerae colony morphology on MacConkey agar

Fig. V. cholerae colony morphology on MacConkey agar

Vibrio cholerae causing haemodigestion on blood agar

Fig. V. cholerae causing haemodigestion on blood agar

Freshly prepared various culture media for Vibrio cholerae

Fig. Freshly prepared various culture media for V. cholerae-Monsur’s taurocholate tellurite peptone water (pH 9.2), Monsur’s gelatin taurocholate trypticase tellurite agar (pH8.5), Gelatin stab medium, and alkaline bile salt agar

Further Reading

  • https://www.nature.com/articles/s41572-018-0005-8
  • https://www.cdc.gov/cholera/pdf/laboratory-methods-for-the-diagnosis-of-vibrio-cholerae-chapter-6.pdf
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4603242/
  • https://www.jpsr.pharmainfo.in/Documents/Volumes/vol11issue02/jpsr11021920.pdf
  • Cowan and Steel’s Manual for identification of Medical Bacteria. Editors: G.I. Barron and  R.K. Felthani, 3rd ed 1993, Publisher Cambridge University Press.
  • Bailey and Scott’s Diagnostic Microbiology. Editors: Bettey A. Forbes, Daniel F. Sahm, and  Alice S. Weissfeld, 12th ed 2007, Publisher Elsevier.
  • Clinical Microbiology Procedure Handbook, Chief in editor H.D. Isenberg, Albert Einstein College of Medicine, New York, Publisher ASM (American Society for Microbiology), Washington DC.
  • Colour Atlas and Textbook of Diagnostic Microbiology. Editors: Koneman E.W., Allen D.D., Dowell V.R. Jr, and Sommers H.M.
  • Jawetz, Melnick and Adelberg’s Medical Microbiology. Editors: Geo. F. Brook, Janet S. Butel & Stephen A. Morse, 21st ed 1998, Publisher Appleton & Lance, Co Stamford Connecticut.
  • Mackie and Mc Cartney Practical Medical Microbiology. Editors: J.G. Colle, A.G. Fraser, B.P. Marmion, A. Simmous, 4th ed, Publisher Churchill Living Stone, New York, Melborne, Sans Franscisco 1996.
  • Textbook of Diagnostic Microbiology. Editors: Connie R. Mahon, Donald G. Lehman & George Manuselis, 3rd edition2007, Publisher Elsevier.
  • https://www.slideshare.net/doctorrao/vibrio-cholera
  • https://www.who.int/cholera/task_force/cholera-rapid-diagnostic-test.pdf
  • https://www.who.int/cholera/task_force/cholera-rapid-diagnostic-test.pdf
  • https://www.cdc.gov/cholera/crystal-vc.html
  • https://www.ncbi.nlm.nih.gov/books/NBK8407/
  • https://www.cdc.gov/cholera/non-01-0139-
Medical Lab Notes

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Medical Lab Notes
Tags: and alkaline bile salt agarand urea agarBacteriaBacterial biochemical testsBiochemical tests of bacteriaBiochemical Tests of Vibrio choleraeCholera Dipstick Test NegativeCholera Dipstick Test PositiveCitrateCitrate and Urease testFreshly prepared various culture media for Vibrio choleraeFreshly prepared various culture media for Vibrio cholerae-Monsur's taurocholate tellurite peptone water (pH 9.2)Gelatin stab mediumGNBGNRGram-negative curved bacillus or comma-shaped Vibrio cholerae in Gram staining of cultureGram-negative curved bacillus or comma-shaped Vibrio cholerae in Gram staining of culture at a magnification of 2000XHanging drop positive for Darting motility of Vibrio choleraeHanging drop positive for Darting motility of Vibrio cholerae at a magnification of 400XIntroduction of Vibrio choleraeKeynotes on VibrioMedicallabnotesMedlabsolutions9MicrohubMonsur's gelatin taurocholate trypticase tellurite agar (pH8.5)mruniverseiOxidation-fermentation (OF) test and Decaboxylase test of Vibrio choleraeOxidation-fermentation (OF) test and Decarboxylase test of Vibrio choleraePrepared hanging drop for Darting motilityPure well isolated Vibrio cholerae yellow colony on TCBS agarRice water stool of a cholera patientserovar Inaba and serovar OdawaSIMSIM TestString Test Positive Vibrio choleraeUniverse84aV. choleraeVibrioVibrio cholaraeVibrio choleraeVibrio cholerae Antisera for O139 (Bengal)Vibrio cholerae Biochemical Reactions in TSIVibrio cholerae causing haemodigestion on blood agaVibrio cholerae causing haemodigestion on blood agarVibrio cholerae colony morphology on 5% sheep blood agarVibrio cholerae colony morphology on MacConkey agarVibrio cholerae colony morphology on nutrient agarVibrio cholerae growth on TCBS agar of watery diarrhea cultureVibrio cholerae growth on TCBS agar of watery diarrhoea cultureVibrio cholerae serotyping for O139 (Bengal)Vibrio colerae Antisera for O139 (Bengal)Vibrio colerae Antisera for serovar InabaVibrio colerae Antisera for serovar OdawaVibrio Footages

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