Sclerotic Bodies: Introduction, Lab Diagnosis, Clinical Significance, and Keynotes

Photomicrograph of Sclerotic Bodies in KOH Mounts from Skin Scrapings of Patients with Suspected Chromoblastomycosis

Introduction Sclerotic Bodies, also known as Medlar Bodies or muriform cells, are thick-walled, pigmented fungal elements typically observed in chromoblastomycosis. Their diagnostic importance lies in their pathognomonic appearance in tissue sections, which confirms the presence of dematiaceous fungi and helps guide appropriate antifungal treatment. Lab …

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