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Xpert MTB-XDR: Introduction, Principle, Procedure, Result-Interpretation, Uses, and Keynotes

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The image shows a GeneXpert software interface displaying an Xpert MTB/XDR test result with M. tuberculosis (MTB) detected and a specific drug resistance profile.Key Findings:MTB DETECTED: Positive for Mycobacterium tuberculosis complex.Low FLQ Resistance DETECTED: Indicates low-level resistance to fluoroquinolones (e.g., levofloxacin or moxifloxacin).Resistance NOT DETECTED: No mutations were found for isoniazid (INH), amikacin (AMK), kanamycin (KAN), capreomycin (CAP), or ethionamide (ETH).This result is consistent with a pre-XDR-TB diagnosis, as there is resistance to fluoroquinolones but susceptibility to second-line injectables.

Introduction The Xpert MTB/XDR assay is an advanced molecular diagnostic tool designed by Cepheid to rapidly detect Mycobacterium tuberculosis complex (MTBC) and its resistance to multiple first- and second-line drugs. Launched in 2021, it is categorized as a “low complexity” automated nucleic acid amplification test …

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