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Introduction Colon cancer is a highly prevalent gastrointestinal malignancy originating from the inner lining (mucosal epithelium) of the large intestine. It ranks as the second leading cause of cancer-related deaths worldwide. While historically more common in older individuals, the incidence has steadily risen in younger …
Introduction Leukemia (also spelled leukaemia) is a group of malignant hematological cancers originating in the bone marrow, characterized by the rapid, uncontrolled proliferation of abnormal, non-functional white blood cells (leukocytes). As these malignant cells accumulate, they crowd out healthy red blood cells, functional white blood …
Introduction NHL begins when lymphocytes (B-cells or T-cells) undergo abnormal changes, causing them to multiply uncontrollably and form tumors. These tumors typically start in the lymph nodes but can spread to other organs like the spleen, liver, or bone marrow. Types of NHLThe NHL is …
Introduction The Xpert MTB/RIF assay is an automated, cartridge-based molecular test used to detect Mycobacterium tuberculosis (MTB) and rifampicin (RIF) resistance, the most potent first-line anti-TB drug. Endorsed by the WHO in 2010, the Xpert MTB/RIF assay revolutionized TB diagnosis by providing results in less than two …
Introduction The Xpert MTB/XDR assay is an advanced molecular diagnostic tool designed by Cepheid to rapidly detect Mycobacterium tuberculosis complex (MTBC) and its resistance to multiple first- and second-line drugs. Launched in 2021, it is categorized as a “low complexity” automated nucleic acid amplification test …
Introduction The Line Probe Assay (LPA) is a rapid molecular diagnostic test used to detect Mycobacterium tuberculosis complex (MTBC) and its resistance to anti-tuberculosis drugs. It identifies specific mutations in the genes associated with drug resistance by hybridizing amplified DNA onto membrane strips. The LPA is a …
Introduction “Rifampicin resistant indeterminate” refers to an unclear or inconclusive result in testing for resistance to the antibiotic rifampicin, often used in the treatment of tuberculosis (TB). Here’s a breakdown of the term: Rifampicin Resistant Result and Cause Indeterminate Result: This means the test did …