NT-proBNP: Introduction, Principle, Procedure, Result Interpretation, Clinical Significance, and Keynotes

Introduction The NT-proBNP (N-terminal pro B-type Natriuretic Peptide) test is a vital cardiac biomarker blood test used primarily to screen for, diagnose, and monitor heart failure. NT-proBNP is a physiologically inactive prohormone fragment released into the bloodstream alongside active BNP when the heart walls stretch …

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MDR-TB to Pre-XDR-TB and XDR-TB Differences: Introduction, Differences, and Critical Clinical Differences

MDR-TB to Pre-XDR-TB and XDR-TB Differences- Introduction, Differences, and Critical Clinical Differences

Introduction The core difference between these forms of drug-resistant tuberculosis (DR-TB) lies in which specific medications the Mycobacterium tuberculosis bacteria can survive. As resistance progresses from MDR-TB to Pre-XDR-TB and finally XDR-TB, treatment becomes longer, more complex, and relies on scarcer second-line drugs. Differences Comparison …

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Colon Cancer: An Overview of Introduction, Types, Pathogenesis,Lab Diagnosis, Treatment, Prevention, and Keynotes

Introduction Colon cancer is a highly prevalent gastrointestinal malignancy originating from the inner lining (mucosal epithelium) of the large intestine. It ranks as the second leading cause of cancer-related deaths worldwide. While historically more common in older individuals, the incidence has steadily risen in younger …

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Non-Hodgkin’s Lymphoma: An Overview of Introduction, Types, Pathogenesis,Lab Diagnosis, Treatment, Prevention, and Keynotes

Introduction NHL begins when lymphocytes (B-cells or T-cells) undergo abnormal changes, causing them to multiply uncontrollably and form tumors. These tumors typically start in the lymph nodes but can spread to other organs like the spleen, liver, or bone marrow. Types of NHLThe NHL is …

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Immunohistochemistry (IHC): Introduction, Application, and Keynotes

Introduction to IHC Immunohistochemistry (IHC) is a powerful laboratory technique that combines anatomical, immunological, and biochemical methods to detect specific antigens (proteins) in tissue sections. By exploiting the principle of antibodies binding specifically to antigens in biological tissues, IHC allows for the visualization of protein …

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Fungal Blood Culture-Mold: Introduction, Principle, Clinical Significance, and Keynotes

Fungal Blood Culture Bottle showing fungal growth

Introduction Molds such as Aspergillus, Fusarium, Scedosporium, and members of the Mucorales are important causes of invasive fungal infections, particularly in immunocompromised patients (oncology, transplant, hematology, ICU). Unlike yeasts (Candida, Cryptococcus), which are more frequently recovered from blood cultures, molds are rarely detected in routine …

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Uremia: Introduction, Diagnosis, Clinical Significance, and Keynotes

Uremic patient's urine under the routine microscopic examination showing numerous red blood cells (RBCs)

Introduction Uremia is a serious condition caused by kidney failure. The word uremia” literally means “urine in the blood. It results when the kidneys cannot remove waste from the blood. Moreover, toxins accumulate and harm vital organs. Patients experience fatigue, nausea, and confusion. Furthermore, they …

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Apolipoprotein A-1 and Apolipoprotein B Ratio- Introduction, Test Result, Unit, Reference Range, Test Methods, Clinical Significance, and Keynotes

Apolipoprotein A-1 and Apolipoprotein B Ratio- Introduction, Test Result, Unit, Reference Range, Test Methods, Clinical Significance, and Keynotes

Introduction Apolipoprotein A-1 (apo A-1) and Apolipoprotein B (apo B) are blood proteins. Moreover, they transport lipids throughout the body. Furthermore, their ratio reflects cardiovascular risk. Consequently, clinicians rely on this ratio for risk assessment. Additionally, the test evaluates lipid metabolism and heart health. Test …

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