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Introduction HLA-B27 (Human Leukocyte Antigen B27) is a specific genetic variant of the HLA-B gene located on chromosome 6. While HLA proteins normally help the immune system distinguish between the body’s own cells and foreign invaders, the B27 variant is a well-known risk factor for …
Introduction Thalassemia is an inherited disorder that disrupts normal hemoglobin production. Patients suffer from anemia and related complications due to defective red blood cells. Moreover, the disorder presents varying severity based on genetic mutations and inheritance patterns. Clinicians diagnose thalassemia using laboratory tests and genetic …
Introduction of Restriction fragment length polymorphisms (RFLPs) Restriction Fragment Length Polymorphisms (RFLPs) are a type of genetic variation found within the DNA of organisms, including humans. They were one of the earliest molecular techniques used for genetic analysis and have played a significant role in …