Molds-Broth Microdilution Testing (CLSI)-Introduction, Principle, Clinical Significance, and Keynotes

Introduction Invasive mold infections such as those caused by Aspergillus, Fusarium, Scedosporium, and Mucorales present significant clinical challenges, especially in immunocompromised hosts. Mortality rates are high, and empirical antifungal therapy often fails due to intrinsic or acquired resistance. Standardized antifungal susceptibility testing (AFST) is therefore …

Read more

Yeasts-Broth Microdilution Testing (EUCAST): Introduction, Principle, Clinical Significance, and Keynotes

Yeasts-Broth Microdilution Testing (EUCAST) Introduction, Principle, Clinical Significance, and Keynotes

Introduction Fungal infections caused by yeasts, particularly Candida and Cryptococcus species, represent a significant clinical challenge in immunocompromised and critically ill patients. Antifungal susceptibility testing (AFST) is crucial for guiding therapy, particularly in cases of treatment failure or the emergence of resistance. The broth microdilution …

Read more