Microtiter plate

Yeasts-Colorimetric Antifungal Susceptibility Testing: Introduction, Principle, Clinical Significance, and Keynotes

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Yeasts-Colorimetric Antifungal Susceptibility Testing-Introduction, Principle, Clinical Significance, and Keynotes

Introduction Yeasts, especially Candida and Cryptococcus species, are frequent causes of opportunistic infections in immunocompromised patients. Determining their antifungal susceptibility is crucial for guiding effective therapy. While broth microdilution methods (CLSI/EUCAST) serve as reference standards, they are labor-intensive and time-consuming. Colorimetric antifungal susceptibility testing systems …

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Molds-Broth Microdilution Testing (CLSI)-Introduction, Principle, Clinical Significance, and Keynotes

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Introduction Invasive mold infections such as those caused by Aspergillus, Fusarium, Scedosporium, and Mucorales present significant clinical challenges, especially in immunocompromised hosts. Mortality rates are high, and empirical antifungal therapy often fails due to intrinsic or acquired resistance. Standardized antifungal susceptibility testing (AFST) is therefore …

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Yeasts-Broth Microdilution Testing (EUCAST): Introduction, Principle, Clinical Significance, and Keynotes

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Yeasts-Broth Microdilution Testing (EUCAST) Introduction, Principle, Clinical Significance, and Keynotes

Introduction Fungal infections caused by yeasts, particularly Candida and Cryptococcus species, represent a significant clinical challenge in immunocompromised and critically ill patients. Antifungal susceptibility testing (AFST) is crucial for guiding therapy, particularly in cases of treatment failure or the emergence of resistance. The broth microdilution …

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