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Introduction KOH Mount of Pleural Fluid is a rapid, direct microscopic test used to detect fungal elements in suspected pleural infections. A 10–20% Potassium Hydroxide (KOH) solution clears cellular debris, fibrin, and protein content in pleural fluid while preserving chitin-rich fungal structures such as hyphae, …
Introduction Sterility testing in a GMP-compliant mycology laboratory is a critical quality assurance process used to confirm that pharmaceutical products, culture media, reagents, water systems, and laboratory environments are free from viable microorganisms, including fungi and yeasts.It follows regulatory guidelines defined by WHO, EU-GMP, USP …
Introduction KOH mount of sputum is a rapid, direct microscopic technique used to detect fungal elements in the respiratory tract. A 10–20% Potassium Hydroxide (KOH) solution digests mucus, epithelial cells, and debris in sputum, while preserving the chitin-rich fungal cell walls, making them appear clear, …
Introduction KOH mount (Potassium Hydroxide preparation) is a rapid, simple, and cost-effective microscopic technique used to detect fungal elements directly in clinical specimens.When applied to Bronchoalveolar Lavage (BAL) samples, it is an essential diagnostic tool for identifying pulmonary fungal infections, especially in the ICU, oncology, …
Introduction Invasive mold infections caused by species such as Aspergillus, Fusarium, Scedosporium, and Mucorales pose serious challenges, especially in immunocompromised and oncology patients. Accurate antifungal susceptibility testing (AFST) is essential for guiding therapy and monitoring resistance trends. The EUCAST (European Committee on Antimicrobial Susceptibility Testing) …
Introduction Direct microscopic examination is one of the most rapid and inexpensive diagnostic methods for detecting fungal elements in clinical specimens. Potassium hydroxide (KOH) smear is a routine technique in mycology that helps visualize fungal structures such as hyphae, yeast cells, and sclerotic bodies directly …
Introduction Histoplasma capsulatum is a dimorphic fungus responsible for histoplasmosis, an endemic mycosis prevalent in parts of North and Central America, Africa, and Asia. In immunocompromised patients, especially those with HIV/AIDS, cancer, or organ transplants, histoplasmosis can be severe and disseminated. Histoplasma antigen testing provides …
Introduction Aspergillus species, particularly Aspergillus fumigatus, are major causes of invasive aspergillosis (IA), especially in immunocompromised patients, such as those with hematological malignancies, transplant recipients, or those with prolonged neutropenia. Diagnosis of IA is often challenging because clinical symptoms and radiological findings are nonspecific. Aspergillus …