This site is fully related to medical laboratory information for public and health care professionals.
In the world of modern diagnostics, speed, accuracy, and comprehensiveness are critical—especially when dealing with complex infections. The latest advancements in targeted next-generation sequencing (tNGS) are redefining how laboratories detect pathogens and manage antimicrobial resistance (AMR). At the core of this innovation is HyPA (Hyperplex …
Fungal infections represent a growing global health challenge, causing over 1.7 million deaths annually, with nearly 75% of cases remaining undiagnosed or diagnosed too late. The increasing burden of antifungal resistance (AMR) further complicates treatment outcomes, highlighting an urgent need for rapid, accurate, and comprehensive …
Introduction Fungal infections represent a growing concern in both immunocompromised and immunocompetent individuals. Conventional identification methods, including culture, microscopy, and biochemical testing, often require several days and may lack sensitivity or specificity for certain opportunistic fungi. Molecular techniques such as PCR and sequencing have improved …
Introduction of MDR Candida NGS MDR Candida NGS refers to the use of Next-Generation Sequencing for the detection, identification, and resistance gene profiling of multidrug-resistant (MDR) Candida species, such as Candida auris, Candida glabrata, and others resistant to azoles, echinocandins, or polyenes. Next-generation sequencing (NGS) …
Introduction Fungal identification by NGS (Next-Generation Sequencing) uses advanced DNA sequencing. Moreover, it rapidly detects diverse fungal species. It enhances diagnostic accuracy. Additionally, it supports personalized treatment decisions. Principle NGS sequences fungal DNA directly. Consequently, it generates millions of short DNA reads. Then, bioinformatics tools …
Introduction to Advanced Molecular Techniques in Clinical Mycology Clinical mycology laboratories play a crucial role in diagnosing and managing fungal infections. Traditional methods like culture and microscopy are often complemented by advanced molecular techniques to improve the accuracy and speed of fungal identification. Among these …