Medical Lab Notes

Rapid Diagnostic Test for Visceral Leishmaniasis (Kala-azar): Introduction, Principle, Procedure, Result-Interpretation, Clinical Significance and Keynnotes

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An InBiOS Detect rapid diagnostic test for Visceral Leishmaniasis (Kala-azar) that appears to show two visible lines, which is consistent with a positive antibody result

Introduction The Rapid Diagnostic Test (RDT) for Visceral Leishmaniasis (VL), often known as the rK39 test or Kalazar Detect™, is a specific, non-invasive immunochromatographic assay used to detect antibodies against Leishmania parasites in human serum or blood. Visceral Leishmaniasis (Kala-azar) is a severe, potentially fatal …

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Non-melanoma skin cancer (NMSC): An Overview of Introduction, Types, Pathogenesis,Lab Diagnosis, Treatment, Prevention, and Keynotes

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Introduction and Types Non-melanoma skin cancer (NMSC) represents a group of cancers that develop in the upper layers of the skin, distinct from melanoma. They are the most commonly diagnosed malignancies worldwide. While they grow slowly and rarely metastasize compared to melanoma, they can cause …

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HLA -B27 Test: Introduction, Principle, Procedure, Result-Interpretation, Clinical Significance, and Keynotes

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Interpretation of HLA-B27 Result_page-0001

Introduction HLA-B27 (Human Leukocyte Antigen B27) is a specific genetic variant of the HLA-B gene located on chromosome 6. While HLA proteins normally help the immune system distinguish between the body’s own cells and foreign invaders, the B27 variant is a well-known risk factor for …

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Infection Prevention & Control and Waste Management: Introduction, Procedure, Waste segregation, Disposal, Application, and Keynotes

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Introduction Infection Prevention and Control (IPC) and Healthcare Waste Management (HCWM) are critical systems used to minimize the spread of pathogens, protecting patients, healthcare workers, and the environment. Approximately 15–25% of healthcare waste is considered hazardous, necessitating strict management protocols. IPC is an evidence-based approach …

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Orientia and Rickettsia: Introduction, Comparison, Key Differences, Treatment and Diagnosis

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Scrub Typhus (Orientia tsutsugamushi) Rapid Test positive and negative results

Introduction Orientia and Rickettsia are two closely related genera of bacteria within the family Rickettsiaceae. Both are small, gram-negative, obligate intracellular pathogens, meaning they can only grow and replicate inside the living cells of their hosts. While they share many clinical features—such as causing fever, …

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Biosafety Officer: Introduction, Roles, Uses, Clinical Significance, and Keynotes

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Importnace of Biosafety Officer

Introduction A Biosafety Officer (BSO) is a technical expert responsible for the strategic and integrated management of biological risks within an organization. Acting as the human component of a biosafety system, they ensure that laboratory practices, containment, and procedures minimize unintentional exposure to pathogens and …

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Immunohistochemistry (IHC): Introduction, Application, and Keynotes

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Introduction to IHC Immunohistochemistry (IHC) is a powerful laboratory technique that combines anatomical, immunological, and biochemical methods to detect specific antigens (proteins) in tissue sections. By exploiting the principle of antibodies binding specifically to antigens in biological tissues, IHC allows for the visualization of protein …

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Tru-Cut Biopsy (Core Needle Biopsy): Introduction, Procedure, Application, and Keynotes

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Introduction A Tru-cut biopsy, also known as a core needle biopsy (CNB), is a minimally invasive diagnostic procedure used to extract a small, solid cylinder (core) of tissue from a suspicious mass. Unlike Fine Needle Aspiration (FNA), which only collects individual cells, a Tru-cut biopsy …

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